PDF Ebook Molecular and Genome Evolution, by Dan Graur
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Molecular and Genome Evolution, by Dan Graur
PDF Ebook Molecular and Genome Evolution, by Dan Graur
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This book describes the driving forces behind the evolutionary process at the molecular and genome levels, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes.
- Sales Rank: #662888 in Books
- Published on: 2016-01-04
- Original language: English
- Dimensions: 11.75" h x 9.25" w x 1.25" l, .0 pounds
- Binding: Hardcover
- 612 pages
About the Author
Dan Graur is John and Rebecca Moores Professor in the Department of Biology and Biochemistry at the University of Houston and Professor Emeritus of Zoology at Tel Aviv University, Israel. Having earned a B.Sc. (Biology) and an M.Sc. (Zoology) at Tel Aviv University, he completed a Ph.D. (Genetics) at University of Texas Health Science Center at Houston. Co-author of two editions of Fundamentals of Molecular Evolution (Sinauer Associates, 1991 and 2000), Dr. Graur has published close to 200 articles, book chapters, encyclopedia entries, commentaries, technical notes, and book reviews. He has served as Associate Editor of Molecular Biology and Evolution (1995-2011) and Genome Biology and Evolution (since 2009). Dr. Graur received an Alexander von Humboldt Research Award in 2011 and, in 2015, was elected a Fellow of the American Association for the Advancement of Science. In addition to his research in molecular and genome evolution, Dr. Graur is interested in the societal implications of genetics and molecular biology.
Most helpful customer reviews
5 of 6 people found the following review helpful.
A brilliant and masterly account of molecular evolution
By John Duncan
Dan Graur has written a masterly account of molecular and genome evolution, and I expect to be getting more and more from it as I re-read and refer to it. As anyone who follows his blog Judge Starling (dan = judge in Hebrew, graur = starling in Roumanian) will know, he is not someone to be discreet about his opinions. His often expressed contempt for the ENCODE project, which cost around $300000 to arrive at the claim that the great majority of the human genome is “functional” makes his blog worth reading for that alone.
As well as explaining protein, nucleic acid structure, mutations and so on in the early chapters, Graur explains in some detail how phylogenetic trees are constructed from molecular data., describing, for example, the simplest method, UPGMA, as well as others such as the widely used computational method, CLUSTAL.
He is not frightened of giving the mathematical basis for his analyses, and assumes that his readers will not be, either. It would be an exaggeration to say that the mathematics is trivial or very simple, but little of it should be beyond the reach of readers who make the effort.
I was particularly interested in his calculation that if 80% of the genome is functional, as claimed, then each of us must have at least 30,000,000,000,000,000,000 children if the population is to avoid collapsing from lethal mutations. As he rightly says, this result is “bonkers”, but there is nothing wrong with the calculation, so the starting point cannot be right. He believes, as I do, that most mutations are neutral, and that the human population can easily avoid collapsing from the genetic load represented by the few that are not. I had read of this calculation in his blog, and I was anxious to check that it was in his book, as I wanted to refer to it in a book of my own.
From time to time Graur injects some sly humour into his presentation. He refers to a class of DNA that he defines Lazarus DNA as rubbish DNA that is mutated to functional DNA, saying that the name comes from “the second most famous resurrected corpse in fiction”.
The only fault worth mentioning is that Graur sometimes shows wrong structures for amino acids and nuceic acid bases: when he first defined an amino acid he said that it contains an amino (-NH2) and a carboxyl (-COOH) group, but that is impossible, because these two groups cannot coexist to any significant extent. On the facing page he has a table showing all the common amino acids in correct ionized forms, but a couple of pages later we are back to uncharged structures, as we also are later in the book. If this were a biochemistry textbook it would be a serious error, as one cannot understand the properties of biological molecules without understanding the ir structures. (A generation or two ago most biochemistry textbooks exhibited the same failure to understand ionization, but today it has largely disappeared.) However, Graur is not a biochemist, and the fault can perhaps be forgiven in a book in which the points being made do not require correct structures.
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